Higher Bute Doses: No Benefit But Higher Risks

A study of bute finds no benefits in higher doses, but higher risks.

New research suggests that increasing a lame horse’s daily dose of bute (phenylbutazone) does not provide greater pain relief, but it does heighten his risk of developing a potentially fatal toxicity.

“It’s common for an owner to start giving a horse a larger dose of bute if the horse doesn’t seem comfortable enough on the current amount–the idea being if some is good, more must be better,” says

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